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降钙素及其受体与骨质疏松的关系 被引量:10

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摘要 骨吸收大于骨形成导致骨重构失衡是骨质疏松(OP)发生的关键,降钙素(CT)主要生理作用是通过直接作用于破骨细胞而抑制骨吸收,同时还具有促进骨合成代谢效应,动物实验及临床试验也均证实了CT在治疗OP中的价值。CT的作用与其受体(CTR)的表达及信号传导密切相关,CT、CTR基因的变异均可导致骨密度的改变,是OP的遗传标志。
出处 《国外医学(老年医学分册)》 2002年第2期91-93,95,共4页 Foreign Medical Sciences(Geriatrics)
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