2-硝基-4-甲氧基苯酚的合成

Study on Synthesis of 2-nitro-4-methoxyphenol

考察了以 2 -硝基 -4 -甲氧基苯胺为原料 ,在碱性条件下水解合成 2 -硝基 -4 -甲氧基苯酚的实验 ;分析了原料配比、反应温度及反应时间对合成反应的影响 ;测定了原料和产物的红外光谱、熔点等物理性质 ;结果表明 ,当 2 -硝基 -4 -甲氧基苯胺 ,NaOH ,水的质量比为 1.0 0∶1.3 3∶71.0 0 ,反应温度为 13 3℃ ,反应时间为 5h时 ,目的产物的产率可达 96% ;

Synthesis of 2-nitro-4-methoxyphenol from alkali hydrolysis of 2-nitro-4-methoxyaniline was studied, with the influence of reactant ratio ,temperature, reaction time on the synthesis analyzed. Melting points and IR spectrums of both feed and product were tested. A 96% yield of target product was obtained in the reaction carried out at 133 ℃ for 5 h, while the reactant ratio (2-nitro-4-methoxyaniline: NaOH: water) was 1.00∶1.33∶71.00. Higher temperature and more NaOH addition were helpful to get a higher conversion of feed and a better yield of product.