绝经后2型糖尿病患者外周血中性粒细胞/淋巴细胞比值与骨密度的关系

Relationship between the blood neutrophil/lymphocyte ratio and bone mineral density in postmenopausal patients with type 2 diabetes

目的探讨绝经后2型糖尿病患者外周血中性粒细胞/淋巴细胞比值(neutrophil lymphocyte ratio,NLR)与骨密度(bone mineral density,BMD)的关系。方法 185例绝经后2型糖尿病患者,根据骨密度值分为骨量正常组、骨量减少组和骨质疏松组。记录所有患者临床资料,检测相关生化指标,测量骨密度,比较三组间的差异,同时分析绝经后2型糖尿病患者NLR与BMD的关系。结果与骨量正常组及骨量低下组相比,骨质疏松组的NLR水平明显升高(P<0.05);偏相关分析提示,控制年龄、病程、绝经年限、体质指数(body mass index,BMI),结果显示绝经后2型糖尿病患者BMD与NLR、三酰甘油(triglyceride,TG)呈负相关(r=-0.470,P<0.001;r=-0.218,P=0.003);多因素线性回归分析提示年龄、病程、绝经年龄、NLR是绝经后2型糖尿病患者BMD的主要影响因素。结论绝经后2型糖尿病患者NLR水平升高,与骨密度相关,说明炎症在骨质疏松的发生发展中起到重要作用。

Objective To explore the relationship between the blood neutrophil/lymphocyte ratio (NLR) and bone mineral density (BMD) in postmenopausal patients with type 2 diabetes mellitus. Methods According to the BMD, a total of 185 postmenopausal patients type 2 diabetes mellitus were classified into normal bone mass group, osteopenia group, and osteoporosis group. The clinical data of all the patients were recorded. The relevant biochemical parameters were detected and BMD was measured. All the parameters were compared among the three groups. At the same time, the relationship between NLR and BMD was analyzed. Results NLR level in the osteoporosis group was significantly higher than that in the normal bone mass group and osteopenia group (P<0.05). When the age, disease course, menopause years, and body mass index (BMI) were adjusted, partial correlation analysis showed that BMD was negatively correlated with NLR and triglyceride (TG) in postmenopausal patients with diabetes mellitus (r=-0.470, P<0.001; r=-0.218, P=0.003). Multiple factor linear regression analysis showed that age, disease course, menopause years, and NLR were main influential factors of BMD in postmenopausal patients with type 2 diabetes. Conclusion The increase of NLR level in postmenopausal patients with type 2 diabetes is related to BMD, indicating that inflammation plays an important role in the occurrence and development of osteoporosis.