胃癌精准医疗时代消化内镜工作面临的问题与对策

Problems and countermeasures of digestive endoscopy on gastric cancer in the era of precision medicine

精准医疗是指与患者分子生物病理学特征相匹配的个体化诊疗策略和过程。规范化的组织标本取材是分子病理学诊断的基础,也是精准医疗的前提。内镜下活检是获取消化道肿瘤(包括胃癌)组织标本的重要途径。本文重点讨论在胃癌精准医疗分子病理学指导下,对胃癌精准医疗过程中组织标本内镜采集工作中的几个问题,并提出相应建议。

Precision medicine is defined as an approach to personalized diagnosis and treatment,based on the omics information of patients.Standardized specimen collection is the basis of molecular pathology diagnosis,which also is the prerequisite for precision medicine.Endoscopic biopsy is an important approach to obtain specimen in gastrointestinal tumors.Here,after summarizing the molecular basis.of gastric cancer related to precision medicine,we propose problems involved in the endoscopic specimen collection,and make recommendations accordingly.