期刊文献+

早期肺腺癌28例临床病理分析 被引量:8

下载PDF
导出
摘要 目的探讨早期肺腺癌的临床病理学特点及预后。方法回顾性分析28例早期肺腺癌的临床病理资料、影像学特点,并复习相关文献。结果 28例中男性10例,女性18例,年龄27~79岁,平均年龄(48. 6±11. 3)岁,体检发现肺部结节等为主要表现。CT平扫可见毛玻璃密度结节。肺内结节0. 25~2. 0 cm,中位数0. 95 cm。切面淡棕色或灰红色,质地软或中等硬度,境界尚清。镜下见肿瘤细胞呈立方形沿原有肺泡壁生长,少数靴钉样向肺泡腔内突起,细胞轻~中度异型,细胞核中等大小,核染色质细腻,核仁不明显,未见肺间质浸润或单个浸润灶,最大浸润范围≤5 mm。28例均表达CK7、TTF-1、Napsin A;均行手术切除术,单纯楔形切除21例,肺段切除5例,肺叶切除2例。随访24~84个月,均无复发及转移。结论早期肺腺癌是浸润性腺癌发展中重要的起始点,明确诊断对临床治疗及患者预后有非常重要的意义。
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2018年第11期1270-1272,共3页 Chinese Journal of Clinical and Experimental Pathology
  • 相关文献

参考文献10

二级参考文献86

  • 1Yoshizawa A, Motoi N, Riely G J, et al. hnpact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognos- tic subgroups and implications for further revision of staging based on analysis of 514 stage I cases [ J ]. Mod Pathol, 2011,24 ( 5 ) : 653 - 64.
  • 2Travis W D, Brarnbilla E, Van Schil P, et ul. Paradigm shifts in lung cancer as defined in the new IASLC/ATS/EFIS lung adeno- carcinoma elassifieation [ J ]. Eur Respir J, 2011,3g (2) :239 - 43.
  • 3Warth A, Muley T, Meister M, et al. The novel histologic Interna- tional Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of survival [ J ]. J Clin Oncol, 2012,30( 13 ) :1438 -46.
  • 4Borczuk A C, Qian F, Kazeros A, et al. Invasive size is an inde- pendent predictor of survival in pulmonary adenocarcinoma[J]. Am J Surg Pathol, 2009,33(3) :462.
  • 5Maeshima A M, Tochigi N, Yoshida A, et al. Histological scoring for small lung adenocarcinomas 2 cm or less in diameter: a reliable prognostic indicator[ J ]. J Thoracic Oncol, 2010,5 (3) :333 - 9.
  • 6Russell P A, Wainer Z, Wright G M, et al. Does lung adcnocarci- noma subtype predict patient survival? A clinicopathologic study based on the new International association for the study of lung cancer/American thoracic society/European respiratory society in- ternational muhidisciplinary lung adenocarcinoma classification [ J 1. J Thoracic Oncol, 2011,6 (9) : 1496 - 504.
  • 7Warth A, Stenzinger A, yon Briinneck A C, et al. Interobserver variability in the application of the novel IASLC/ATS/ERS classifi- cation for pulmonary adenocarcinomas[ J1. Eur Respir J, 2012,40 (5) :1221 -7.
  • 8P-Ares L, Soulires D, Melezfnek I, et al. Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations : pooled a- nalysis[ J]. J Cell Mol Med, 2010,14 ( 1 - 2) :51 - 69.
  • 9Yasuda H, Kobayashi S, Costa D B. EGFR exon 20 insertion mu-tations in non-small-cell lung cancer: preclinical data and clinical implications[ J]. Lancet Oneol, 2012,13 ( 1 ) : e23 - 31.
  • 10Takahashi T, Kobayashi M, Yoshizawa A, et al. Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene [J]. Ann Surg Oneol, 2010,17(3) :889 -97.

共引文献1406

同被引文献64

引证文献8

二级引证文献45

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部