脓毒症的免疫抑制

Immunosuppression of sepsis

脓毒症是多种炎性因子影响免疫功能而导致的感染性疾病,是ICU患者主要的死亡原因。脓毒症作为一种由不可控炎症引起的综合征,包含大量且持续的炎症反应以及长期的免疫抑制状态,这会增加脓毒症患者继发院内感染的发生率。脓毒症患者的免疫状态会随着病程发展不断变化,不同的生物标志物有助于识别患者所处的免疫阶段。免疫增强治疗有望降低免疫麻痹的脓毒症患者的病死率。

Sepsis is an infectious disease that affects immune function by various inflammatory factors and is the main cause of death in ICU patients.As a syndrome caused by uncontrollable inflammation,sepsis not only contains a large number of continuous inflammatory reactions,but also has a long-term immunosuppressive state,which increases the probability of secondary nosocomial infection in patients with sepsis.The immune status of patients with sepsis will change with the progression of the disease,and different biomarkers help to explain the immune stage of patients.Immune-enhancing therapy is expected to reduce the mortality rate of sepsis patients in the stage of immunoparalysis.