Notch信号通路调控CD4+CD25+CD127dim/-调节性T细胞和Th17细胞平衡在急性心肌梗死中的作用被引量：3

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摘要初始CD4^+T细胞根据在不同转录因子和细胞因子的作用下可分化为不同的辅助性T细胞亚群。CD4^+CD25^+CD127^dim/-调节性T细胞(Tregs)高表达转录因子FoxP3,主要通过分泌白细胞介素(IL)-10和IL-35抑制免疫应答;Th17细胞表达维甲酸相关孤独核受体γt(尚罕见,RORγt),可分泌IL-17和IL-22促进炎症应答^[1]。冠心病患者中存在Tregs和Th17细胞失衡^[2],Notch信号通路在丙型肝炎^[3]、免疫性血小板减少症^[4]、哮喘等^[5]疾病中可调控Tregs和Th17细胞的失衡,但尚罕见此调控作用在冠心病中的研究。

作者冯金花赵统秀

机构地区青海省人民医院全科医学科

出处《中华医学杂志》 CAS CSCD 北大核心 2018年第45期3716-3718,共3页 National Medical Journal of China

关键词 Notch信号通路 Th17细胞调节性T细胞调控作用急性心肌梗死转录因子FOXP3 CD4^+CD25^+ 免疫性血小板减少症

分类号 R542.22 [医药卫生—心血管疾病]

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1周学亮,方义湖,赵勇,邹斌,许起荣,徐华,饶长秀,刘季春.Notch1减轻心肌缺血再灌注损伤作用的研究[J].中华医学杂志,2016,96(20):1591-1596. 被引量：4

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