T细胞、CD4^+T细胞与转移复发性三阴性乳腺癌的预后关系

Relationship between lymphopaenia of different T cell subtypes and prognosis of metastatic recurrent triple negative breast cancer

目的探讨转移复发性三阴性乳腺癌患者外周血中T细胞及其亚群(CD4^+T细胞、CD8^+T细胞)减少与患者中位无进展生存(mPFS)及中位总生存(mOS)间的关系。方法133例转移复发性三阴乳腺癌患者一线化疗前,用流式细胞仪检测患者外周血T细胞、CD4^+T细胞、CD8^+T细胞的数目。对患者进行为期5年的随访,探讨T细胞及其亚群与转移性三阴性乳腺癌的预后间的关系。结果转移复发性三阴性乳腺癌患者mPFS、mOS长短与外周血中T细胞及CD4^+T细胞数量相关(P<0.05);mPFS、mOS长短与CD8^+T变化无关(P>0.05)。结论转移复发三阴性乳腺癌患者的外周血T细胞数量和CD4^+T数量可作为判断患者预后的指标。

Objective To discuss the association between peripheral blood T cells lymphopaenia,CD4^+T cells lymphopaenia,CD8^+T cells lymphopaenia and median progressive free survival(mPFS),median overall survival(m OS)in patients with recurrent triple negative breast cancer. Methods The number of peripheral blood T cells,CD4^+T cells and CD8^+T cells in133 patients with recurrent triple negative breast cancer were determined by flow cytometry before first line of chemotherapy.Patients were followed up for 5 years to investigate the relationship between T cells and their subpopulations and the prognosis of metastatic triple-negative breast cancer. Results The length of mPFS and mOS in patients with recurrent triplenegative breast cancer were correlated with T cells and CD4^+T cells in peripheral blood(P<0.05). The length of mPFS and mOS was not correlated with CD8^+T(P>0.05). Conclusion The number of peripheral blood T cells and the number of CD4^+T in patients with metastatic recurrent triple-negative breast cancer could be used as indicators to judge the prognosis of patients.