重组牛碱性成纤维细胞生长因子联合玻璃酸钠治疗干眼症的疗效分析

Clinical effect of combination therapy of sodium hyaluronate and recombinant bovine basic fibroblast growth factor on dry eye after phacoemulsification

目的分析使用重组牛碱性成纤维细胞生长因子(r-bFGF)联合玻璃酸钠(SH)对白内障超声乳化术后干眼症泪膜的影响。方法将2014年7月至2017年6月于行白内障超声乳化术后1个月内诊断干眼症的患者96例(102眼)随机分为治疗组48例(50眼)与对照组48例(52眼),对纳入患者进行相应检查及症状评分。对照组给予0.1%玻璃酸钠滴眼液治疗,治疗组给予重组牛碱性成纤维细胞生长因子联合玻璃酸钠滴眼液治疗。治疗后1个月进行干眼症检查及症状评分。结果治疗前两组间各项指标差异不具有统计学意义。治疗后治疗组的基础泪液分泌值、非侵犯性泪膜破裂时间值、中央泪河高度值、角膜荧光染色评分和主观干眼感觉评分优于对照组,差异具有统计学意义;治疗后治疗组脂质层分析评分与对照组的差异不具有统计学意义。结论重组牛碱性成纤维细胞生长因子联合玻璃酸钠滴眼液对治疗白内障超声乳化术后干眼症具有显著疗效。

Objective To analyze the effect of sodium hyaluronate( SH) and recombinant bovine basic fibroblast growth factor( r-bFGF) on tear film of dry eye after phacoemulsification surgery. Methods Among patients diagnosed with dry eye within one month of phacoemulsification surgery who presented to our hospital between July 2014 and June 2017,96 cases( 102 eyes) were randomly divided into a treatment group( 48 cases,50 eyes) and a control group( 48 cases,52 eyes). All enrolled patients underwent dry eye examination and grading. The control group was administered 0.1% SH,while the treatment group was treated with eye drops containing SH and r-bFGF. After one month of treatment,all patients underwent dry eye-related examination and grading again. Results No statistically significant differences were observed in any of the indexes between the two groups before initiating treatment. After treatment,the Schirmer I test results,non-invasive tear film break-up time,tear meniscus height,corneal fluorescein staining and ocular symptoms scores of the treatment group were significantly better than those of the control group,with a statistically significant difference. Difference in the tear film lipid layer scores between the treatment and control groups was not statistically significant. Conclusion SH combined with r-bFGF has a significant effect on dry eye after phacoemulsification surgery.