血清镁浓度与中国成人肥胖的关系

Relationship between serum magnesium concentration and obesity in Chinese adults

目的了解中国居民血清镁浓度与超重肥胖和腹型肥胖的关系。方法对中国健康与营养调查(CHNS) 2009年的调查数据进行分析,采用秩相关分析、单因素分析和Logistic回归分析比较不同血清镁浓度、省份和性别对超重肥胖和腹型肥胖患病率的影响。结果超重肥胖率为40. 2%,其血清镁浓度高于非超重人群(0. 95mmol/L vs. 0. 93 mmol/L,t=7. 021,P <0. 001),腹型肥胖率为33. 2%,其血清镁浓度高于非腹型肥胖人群(0. 95 mmol/L vs. 0. 93 mmol/L,t=5. 712,P <0. 001)。富镁省份人群中平均血清镁浓度、超重肥胖率和腹型肥胖率均高于非富镁省份,差异有统计学意义(血清镁浓度:t=8. 012,P <0. 001;超重肥胖:χ~2=138. 252,P <0. 001;腹型肥胖:χ~2=134. 999,P <0. 001)。血清镁浓度与超重肥胖率和腹型肥胖率的秩相关系数在男性中分别为0. 952和0. 796,女性中分别为0. 794和0. 903。血清镁浓度按四分位数分为四个等级时,每增加一个等级,发生超重肥胖的危险增加为1. 207倍(95%CI 1. 138～1. 281),发生腹型肥胖的危险增加为原来的1. 187倍(95%CI 1. 114～1. 266)。结论血清镁浓度升高可能是中国成人超重肥胖和腹型肥胖的危险因素,血清镁浓度与肥胖率呈中度甚至高度相关,且这种相关性存在性别差异。

Objective To explore the relationship between concentration of serum magnesium with overweight/obesity and abdominal obesity in Chinese adults.Methods Data from China Health and Nutrition Survey investigated in 2009 was analyzed.Rank correlation analysis,univariate analysis and binary Logistic regression analysis were performed to analyze influence of serum magnesium concentrations,regions and gender on the prevalence of overweight/obesity and abdominal obesity.Results The prevalence of overweight/obesity was 40.2%.The concentration of serum magnesium in people with overweight/obesity was higher than that in people with non-overweight/obesity (0.95 mmol/L vs.0.93mmol/L,t =7.021,P <0.001).The prevalence of overweight/obesity was 33.2%.The concentration of serum magnesium in people with abdominal obesity was higher than that in people with non-abdominal obesity (0.95mmol/L vs.0.93mmol/L, t =5.712,P <0.001).The serum magnesium concentration,prevalence of overweight/ obesity and abdominal obesity were higher in magnesium-rich area than in the nonmagnesium-rich areas,which showed significant differences between two groups (serum magnesium:t =8.012,P <0.001;overweight/obesity:χ^2=138.252,P <0.001; abdominal obesity :χ^2=134,999,P <0.001).The rank correlation coefficients between serum magnesium concentration and prevalence of overweight/obesity and abdominal obesity were 0.952 and 0.796 in male,and 0.794 and 0.903in female,respectively. Serum magnesium concentration was divided into four grades according to quartiles.The risk of overweight/obesity increased by 1.207times(95%CI 1.138-1.281)when the serum magnesium increased a level,and the risk of abdominal obesity increased by 1.187 times (95%CI 1.114-1.266).Conclusion Higher serum magnesium concentration may be a risk factor for overweight/obesity and abdominal obesity.Serum magnesium concentration is moderately and even highly correlated with prevalence of obesity,and there is a gender difference in this relationship.