摘要
肿瘤相关成纤维细胞(CAF)是肿瘤微环境的最主要成分之一,对肿瘤的发生、发展、浸润及转移具有极其重要的作用,在多种实体肿瘤中其甚至可决定肿瘤细胞的命运。鉴于CAF在推动肿瘤进展方面的关键作用,因而CAF最近已经成为多种肿瘤的治疗靶点,但在血液系统肿瘤中CAF相关研究尚少。新近研究发现,急性髓系白血病(AML)、多发性骨髓瘤(MM)、慢性淋巴细胞白血病(CLL)等多种血液恶性肿瘤的耐药、复发及骨髓增殖性肿瘤(MPN)骨髓纤维化的发生、发展与CAF密切相关,靶向CAF可有效提高化疗药物对肿瘤细胞的杀伤效应,进而提高疗效,因而有望成为血液系统肿瘤治疗的新靶点。本文总结了近年来肿瘤相关成纤维细胞在血液系统恶性肿瘤中的研究进展。
Cancer-associated fibroblasts (CAF), as one of the most important components of tumor microenvironment,which plays important role in tumorigenesis, development, infiltration and metastasis of cancers.In a variety of solid tumors, CAF can even determine the fate of tumor cells.In view of its pivotal role in promoting tumor progression,CAF has recently become a therapeutic target for a variety of tumors.However, there are a few studies on CAF in hematological malignancies.Recent studies have found that the resistance, relapse of AML, MM, CLL and myelofibrosis of MPN closely relate with CAF, so targeting CAF can effectively enhance the killing effect of chemotherapy drugs on tumor cells, thus improve the efficacy, CAF is expected to become a new target for the treatment of hematological malignancies.This review summarizes recent advances in cancer-associated fibroblasts in hematological malignancies.
作者
潘成云
许娜
刘晓力
周璇
李艳菊
王季石
PAN Cheng-Yun;XU Na;LIU Xiao-Li;ZHOU Xuan;LI Yan-Ju;WANG Ji-Shi(Department of Hematology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou Province,China;Department of Hematology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2018年第6期1872-1875,共4页
Journal of Experimental Hematology