巨核细胞发育和血小板生成的调控

Regulation of the Megakaryocyte Development and the Platelet Production——Review

巨核细胞的主要生理功能是产生血小板,其发育、成熟和血小板生成是多因素参与的复杂调控过程。近年来研究发现,除骨髓之外,肺也是巨核细胞生成血小板的主要场所。本综述以近年的研究结果为基础,概述了巨核细胞发育、成熟及血小板生成的过程,重点解析了凋亡因子、miRNA、血小板生成素及其受体、白介素、转录因子及相应的信号转导通路对血小板生成的调控作用。了解血小板生成调控机制,可有助于了解血小板相关疾病的病理机制,为临床上血小板相关疾病的诊断及治疗提供新思路。

The main physiological function of megakaryocytes is the production of platelets, whose development,maturation and platelet production are a complex regulatory process, and are involved in many factors.In recent years it was found that the lung is also the main site of megakaryocyte-producing platelets in addition to bone marrow.Based on the findings of recent years, this review summarizes the process of megakaryocyte development, maturation and platelet production, with emphasis on the analyzing the regulatory effects of apoptotic factors, miRNA, thrombopoietin and its receptors, interleukins, transcription factors and their corresponding signal pathways on platelet production.To understand the regulatory mechanism of platelet production can help to understand the pathological mechanism of platelet-related diseases and provide new ideas for the diagnosis and treatment of platelet-related diseases.