痤疮丙酸杆菌抗生素耐药性研究进展

Advances in Antibiotic Resistance of Propionibacterium Acnes

痤疮丙酸杆菌是皮肤共生菌,在痤疮炎性皮损的形成过程中占有重要地位。抑制或杀灭痤疮丙酸杆菌,能够有效控制及治疗痤疮。然而抗生素的广泛使用,使痤疮丙酸杆菌对痤疮常用抗生素产生耐药。耐药菌株的存在使得痤疮患者抗生素疗效降低,甚至引起其他耐药细菌出现,改变人类的微生物群组,增加机体其他细菌感染的机会。研究痤疮丙酸杆菌耐药情况及机制,有利于痤疮的治疗。

Propionibacterium acnes(P. acnes) is human skin commensal bacterium,which plays an important role in the development of acne lesions. We can effectively control and treat acne through inhibiting or killing P. acnes. However,the widespread use of antibiotics led to development of P. acnes resistant to antibiotics. This decreased efficacy of antibiotic treatments for acne,even caused the emergence of other resistant bacterial species,leading to the alteration of human microbial population,what contributes to increased risk of other bacterial infections. To improve the efficacy of the treatment for acne we need to understand P. acnes antibiotic resistance.