舌鳞状细胞癌放疗后骨肉瘤1例报告及文献复习

Radiation-induced osteosarcoma in patient with tongue squamous cell carcinomas:a case report and review of the literature

放疗诱发肉瘤(radiation induced sarcoma,RIS)是放射治疗后一种少见而严重的并发症,在全身多个部位的原发肿瘤放疗后均有报道,其恶性程度高,预后差,在临床诊断及治疗上均有极大难度。本文报告1例舌鳞状细胞癌放疗后诱发下颌骨骨肉瘤,同时伴发舌、口底第二原发癌的患者,并结合国内外文献,对头颈部放疗诱发肉瘤(radiationinduced sarcoma of head and neck,RISHN)的发病因素、诊断标准、临床特点、治疗及预后进行讨论。

Radiation induced sarcoma(RIS),which is a rare,serious and highly malignant complication of cancer radiation therapy,has been documented in a series of primary cancers from different parts of the body.Due to the difficulty in diagnosis and therapeutic management,the prognosis is still poor.Herein,we reported a case of radiation-induced osteosarcoma and second primary tumors(SPTs) in a patient with tongue squamous cell carcinomas and reviewed relevant literatures.The epidemic factors,diagnostic criteria,clinical manifestation,treatment and prognosis of radiationinduced sarcoma of head and neck(RISHN) were discussed.