针灸对帕金森病患者血清MDA、SOD及胱抑素C水平的影响

Influence of Acupuncture on Serum MDA, SOD and Cystatin C in Parkinson′s Disease Patients

目的:观察针灸对帕金森病患者血清丙二醛(MDA)、超氧化物歧化酶(SOD)及胱抑素C水平的影响。方法:将106例帕金森病患者随机分为两组各53例。对照组患者采用复方卡比多巴片治疗,治疗组患者在对照组基础上采用针灸治疗,两组均以3个月为1个疗程。治疗结束后,比较两组患者治疗前后血清MDA、SOD及胱抑素C水平变化,并对比两组患者病情(UPDRS)和生活质量(PDQ-39)改善情况,并根据UPDRS改善情况评定临床疗效。结果:两组疗效比较,治疗组优于对照组,差异有统计学意义(P<0.05)。两组患者治疗后血清MDA、血清胱抑素C水平均较治疗前降低,SOD水平均增加,差异均有统计学意义(P<0.05);治疗组患者治疗后血清MDA、血清胱抑素C水平均低于对照组,SOD水平高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后UPDRS、PDQ-39评分均较治疗前降低,差异均有统计学意义(P<0.05);治疗组患者治疗后UPDRS、PDQ-39评分均低于对照组,差异均有统计学意义(P<0.05)。结论:针灸治疗帕金森病可改善患者病情,提高生活质量,缓解炎症反应,抗氧化应激。

Objective:To observe the influence of acupuncture on MDA,SOD and Cystatin C in parkinson's disease patients.Methods:A total of 106 patients were randomly divided into two groups,with 53 cases in each group.The control group was treated by compound carbidopa tablets,and the treatment group was treated with acupuncture on the basis of the control group.The two groups were treated with 3 months as a course of treat- ment.After the end of treatment,the changes of serum MDA,SOD and cystatin C were compared between the two groups before and after treatment.The improvement of UPDRS and quality of life (PDQ-39)were compared between the two groups.The clinical efficacy was evaluated according to the improvement of UPDRS.Results: The curative effect of the treatment group was better than that of the control group (P<0.05).After treatment,the levels of serum MDA and cystatin C were decreased,and the levels of SOD were increased in both groups (P< 0.05).The levels of serum MDA and cystatin C in the treatment group were lower than those in the control group,and the levels of SOD were higher than those in the control group (P<0.05).The UPDRS and PDQ-39 scores of the two groups were significantly lower than those before treatment (P<0.05).After treatment,the scores of UPDRS and PDQ-39in the treatment group were lower than those in the control group after treatment (P< 0.05).Conclusion:Acupuncture can improve the parkinson's disease patient's condition,enhance the quality of life,alleviate inflammation and responses to antioxidant stress.