血管性痴呆中医病机及人参皂苷益智机制研究进展

Research progress of TCM pathogenesis of vascular dementia and the nootropic mechanism of ginsenosides

据统计中国现有痴呆患者700～800万,其中血管性痴呆(VaD)占10%～20%。然而VaD的具体发病机制至今并不明确,王永炎院士曾提出VD"正虚毒损络阻"的病机学说,且《神农本草经》中也有人参"益智"作用的论述。基于VaD中医病机的探讨及临床实践,我们认识到中药人参对认知改善的确切作用,而人参皂苷作为人参的有效成分,其益智机制尚不明确。故而,文章从VaD的中医病机以及人参皂苷益智机制的相关研究进展两个方面进行综述。

According to statistics,there are 7-8 millions of dementia patients in China,of which vascular dementia (VaD)accounts for 10%-20%.However,the specific pathogenesis of VaD is not clear to date.Academician WANG Yong-yan once puts forward the ‘ZhengXuDuSun'theory of VaD and Shen Nong's Herbal Classic has been recorded on the nootropic function of Chinese medicine ginseng.Based on the discussion of TCM pathogenesis of VaD and clinical practice,We recognize the exact effect of Chinese medicine ginseng on cognitive improvement,but the nootropic mechanism of Ginsenosides is not clear as an effective component of ginseng.So two aspects of the research progress of TCM pathogenesis of VaD and the nootropic mechanism of ginsenosides are discussed in this paper.