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还原型谷胱甘肽联合腺苷蛋氨酸及维生素C片对妊娠期肝内胆汁淤积症患者肝功能及母婴结局的影响 被引量:9

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摘要 目的:探讨还原型谷胱甘肽联合腺苷蛋氨酸及维生素C片对妊娠期肝内胆汁淤积症(ICP)患者肝功能及母婴结局的影响。方法:选择我院ICP患者102例,按随机抽签法分为对照组(n=51)与观察组(n=51)。对照组采取腺苷蛋氨酸及维生素C片治疗,观察组采取还原型谷胱甘肽联合腺苷蛋氨酸及维生素C片治疗,均治疗1个月。比较两组母婴结局与治疗前、治疗1个月后血清肝功能指标[总胆红素(TBIL)、谷草转氨酶(AST)、谷丙转氨酶(ALT)]水平。结果:观察组治疗1个月后血清TBIL、AST、ALT水平低于对照组,差异有统计学意义(P<0.05);观察组早产、产后出血、胎儿窘迫、新生儿窒息等不良母婴结局发生率低于对照组,差异有统计学意义(P<0.05)。结论:妊娠期肝内胆汁淤积症予以还原型谷胱甘肽联合腺苷蛋氨酸及维生素C片治疗可显著减轻肝功能损伤,改善母婴结局。
作者 周顺平
出处 《北方药学》 2019年第1期51-52,共2页 Journal of North Pharmacy
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