期刊文献+

32例脑梗死患者阿司匹林抵抗的临床特征及相关因素分析 被引量:4

下载PDF
导出
摘要 探讨脑梗死患者阿司匹林抵抗(AR)的临床特征,并分析影响因素。方法:选取我院2014年1月~2017年1月124例脑梗死住院治疗患者,根据服用阿司匹林治疗后血小板计数情况分为阿司匹林抵抗患者(AR组,n=32)、阿司匹林敏感患者(AS组,n=64),以及阿司匹林半抵抗患者(n=28,剔除);统计对比临床资料包括性别、糖尿病、高血压、冠心病、年龄、吸烟、体重指数等临床特征以及生化指标水平,并进行因素分析。结果:AR组女性占比高于AS组,合并糖尿病患者占比高于AS组,HbAlc、LDL、Hcy水平高于AR组(P<0.05);经logistic多因素分析可知,女性、合并糖尿病为AR发生的独立危险因素(P<0.05)。结论:脑梗死患者中女性以及合并糖尿病发生AR风险较高,Hcy升高、HbAlc升高、LDL升高均为AR发生的影响因素,临床治疗脑梗死时应注意定期检测,尤其关注女性患者以及合并糖尿病患者。
出处 《北方药学》 2019年第1期103-104,共2页 Journal of North Pharmacy
基金 许昌市科技攻关项目20170213249
  • 相关文献

参考文献4

二级参考文献27

  • 1Lordkipanidz6 M, Pharand C, Schampaert E, et al. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease [ J ]. Eur Heart J, 2007, 28(14) :1702-1708.
  • 2Pearson TA,Mensah GA,Alexander RW,et al. Markers of inflammation and cardiovascular disease:application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association [ J ]. Circulation,2003,107 (3) :499-511.
  • 3Weber AA, Przytulski B, Schanz A, et al. Towards a definition of aspirin resistance: a typological approach [ J]. Platelets ,2002, 13 ( 1 ) :37-40.
  • 4Collet JP, Montalescot G. Platelet function testing and implications for clinical practice [ J ]. J Cardiovasc Pharmacol Ther, 2009, 14 (3) : 157-169.
  • 5Blais N, Pharand C, Lordkipanidz6 M, et al. Response to aspirin in healthy individuals. Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B ( 2 ) [ J ]. Thromb Haemost, 2009, 102 ( 2 ) :404 -411.
  • 6Santilli F, Rocca B, De Cristofaro R, et al. Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin " resistance" [ J ]. J Am Coll Cardiol, 2009, 53 (8) :667-677.
  • 7Englyst NA, Horsfield G, Kwan J, et al. Aspirin resistance is more common in lacunar strokes thanembolic strokes and is related to stroke severity[ J ]. J Cereb Blood Flow Metab, 2008, 28(6):1196-1203.
  • 8Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients [ J ]. BMJ, 2002, 324 (7329) : 71-86.
  • 9Linnemann B, Schwonberg J, Toennes SW, et al. Variability of residual platelet function despite clopidogrel treatment in patients with peripheral arterial occlusive disease [ J ]. Atherosclerosis, 2010, 209 (2) : 504-509.
  • 10Lev EI. Aspirin resistance transient laboratory finding or important clinical entity [ J ]. J Am Coll Cardiol, 2009, 53 ( 8 ) :678-680.

共引文献39

同被引文献42

引证文献4

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部