利奈唑胺治疗金黄色葡萄球菌感染的疗效和安全性

Efficacy and safety of linezolid in the treatment of Staphylococcus aureus infection

目的:研究利奈唑胺治疗金黄色葡萄球菌感染临床效果和安全性。方法:将78例金黄色葡萄球菌感染患者随机分为对照组和研究组,每组39例,对照组给予万古霉素治疗,研究组给予利奈唑胺治疗。监测两组用药一周后的临床症状、血培养结果,肝肾功能变化、病原学改变及出现的不良反应。结果:研究组总有效率显著高于对照组(100.00%VS 84.62%,P<0.05),不良反应发生率显著低于对照组(15.38%VS 30.77%,P<0.05)。结论:利奈唑胺治疗金黄色葡萄球菌感染疗效显著,安全可靠。

Objective:Evaluation of the clinical efficacyand safety of infection with linezolid in the treatment of Staphylococcus aureus. Methods:78patients with Staphylococcus aureus infection were randomly divided into a control group and a study group,with 39patients in each group.Patients in the control group were treated with vancomycin,and the study group was treated with linezolid.Monitor the clinical symptoms,blood culture results,liver and kidney function changes,etiological changes and adverse reactions of patients in the two groups after one week of medication.Results:The total effective rate of the study group was significantly higher than that of the control group (100.00%VS 84.62%,P<0.05),and the incidence of adverse reactions was significantly lower than that of the control group (15.38%VS 30.77%,P<0.05).Conclusion:Linezolid is effective and safe in the treatment of Staphylococcus aureus in hospitals.