多囊卵巢综合征患者体内总睾酮水平与糖、胰岛素及性激素水平的相关性分析

An Analysis on the Correlations Between Total Testosterone Level and Glucose,Insulin and Sex Hormones Levels in Women with Polycystic Ovary Syndrome

目的研究多囊卵巢综合征(PCOS)患者体内血清总睾酮(TT)与糖、胰岛素及性激素水平的相关性。方法选择在我院就诊的PCOS患者194例,分别记录或测定其年龄、BMI、血清TT、空腹血糖、空腹胰岛素和性激素相关指标[硫酸脱氢表雄酮(DHEAS)、性激素结合球蛋白(SHBG)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_2)、孕酮(PO)及催乳素(PRL)],并对其进行统计分析。结果 TT高值组的BMI和DHEAS明显高于TT低值组[TT高值组的BMI和DHEAS分别为28.55(25.01～30.49)kg/m^2、218.00(155.00～327.00)μg/dL;TT低值组的BMI和DHEAS分别为27.06(23.00～29.30)kg/m^2、198.00(142.00～254.00)μg/dL],差异具有统计学意义(P<0.05)。TT高值组的年龄及P0明显低于TT低值组[TT高值组的年龄和PO分别为26.1±4.8岁、0.39(0.24～0.64) ng/mL;TT低值组的年龄和PO分别为27.5±4.1岁、0.46(0.32～1.10)ng/mL],差异具有统计学意义(P <0.05)。血清TT水平与DHEAS正相关,而与年龄负相关(r值分别为0.221和-0.213),具有统计学意义(P<0.05)。结论 TT水平与血糖及胰岛素水平无相关性,但与具有低水平TT的患者相比,具有高水平TT的多囊卵巢综合征患者更加年轻、易发生肥胖,且具有较差的性激素水平。

Objective To study the associations of total testosterone (TT)level and the serum glucose,insulin and sex hormones levels in women with polycystic ovary(PCOS).Methods One hundred and ninety-four untreated women with PCOS were enrolled for the study.The levels of serum TT,glucose,insulin and sex hormones [dehydroepiandrosterone sulfate (DHEAS),sex hormone binding globulin (SHBG),follicle stimulating hormone (FSH),luteinizing hormone (LH ),estradiol (E2),progesterone (PO )and prolactin (PRL )]were measured,and the results were then analyzed.Results The BMI and DHEAS levels were significantly higher, while the age and PO levels were significantly lower in the higher TT Group compared with the lower TT group (P <0.05).The BMI and DHEAS in the higher TT Group were 28.55(25.01-30.49)(kg/m^2)and 218.00 (155.00-327.00)μg/dL,respectively,and those in the lower TT Group were 27.06(23.00-29.30)kg/m^2 and 198.00(142.00-254.00)μg/dL,respectively.The age and PO in the higher TT Group were 26.1±4.8 years and 0.39(0.24-0.64)ng/mL,respectively,and those in the lower TT Group were 27.5±4.1 years and 0.46 (0.32-1.10)ng/mL,respectively.The TT level was positively correlated with the DHEAS level,but inversely related to age(P <0.05).The values of r were 0.221 and -0.213,respectively.Conclusion The level of TT is not related to the serum levels of glucose and insulin,but the patients with high level of TT tend to be younger and more prone to obesity,and have poor sex hormone level.