呼吸运动对质子调强放疗的影响及研究进展

Effect and research progress of respiratory motion on intensity-modulated proton therapy

相比于光子调强放疗,质子调强放疗有明显的剂量优势。质子的布拉格峰比较陡峭.容易受射程偏差、摆位偏差、器官形变等因素的影响。呼吸运动造成的计划剂量和实际照射剂量之间的差异阻碍了质子调强放疗在胸部肿瘤中的广泛应用。本文综述了呼吸运动对质子调强放疗的影响及减小这种影响的研究进展,为临床和研究提供参考。

Compared with intensity-modulated photon therapy,intensity-modulated proton therapy has significant dose advantages.However,the dose gradient of proton Bragg peak is relatively high,and the proton therapy is likely to be affected by range uncertainties,setup uncertainties and antonymic changes,etc. The difference between the planning dose and actual dose caused by respiratory motion hinders the widespread use of intensity-modulated proton therapy in thoracic cancers.In this paper,research progress on the effect of respiratory motion on intensity-modulated proton therapy and how to reduce the effect were summarized,aiming to provide reference for clinicians and researchers.