多烯磷脂酰胆碱治疗妊娠期肝内胆汁淤积症的疗效及对妊娠结局的影响效果观察

Effect of Polyphosphatidylcholine on Intrahepatic Cholestasis During Pregnancy and its Effect on Pregnancy Outcome

目的研究在妊娠期肝内胆汁淤积症中采取多烯磷脂酰胆碱治疗的临床应用效果。方法此次验证收治的样本为2012年3月至2017年6月收治的50例妊娠期肝内胆汁淤积症患者,依据随机法将样本平均分组,每组25例,将常规治疗用于参照组,将多烯磷脂酰胆碱治疗应用实验组,对两组妊娠期肝内胆汁淤积症患者组间比对差异进行研究。结果实验组妊娠期肝内胆汁淤积症患者阴道分娩率、产后出血、新生儿宫内窘迫、新生儿窒息、早产、新生儿体重、分娩孕周和参照组相关数值对比,统计学计算分析意义存在(P<0.05)。结论将多烯磷脂酰胆碱治疗应用在妊娠期肝内胆汁淤积中有利改善妊娠结结局。

Objective To study the clinical effect of polyene phosphatidylcholine in the treatment of intrahepatic cholestasis during pregnancy. Methods A total of 50 patients with intrahepatic cholestasis during pregnancy admitted between March 2012 and June 2017 were included in this study. According to the random method, the samples were grouped evenly, 25 cases per group. Routine treatment was applied to the reference group, and polyenophosphatidylcholine was applied to the experimental group. The comparison between the two groups of patients with intrahepatic cholestasis during pregnancy was studied. Results The rate of vaginal delivery, postpartum hemorrhage, neonatal intrauterine distress, neonatal asphyxia, preterm birth, neonatal weight, gestational age and reference group were compared in the experimental group. Statistical analysis was performed with significance(P<0.05). Conclusion The application of polyene phosphatidylcholine in hepatobiliary stasis during pregnancy can improve the outcome of pregnancy.