局部应用氨甲环酸干预股骨粗隆间骨折股骨防旋髓内钉内固定术后隐性失血的疗效

Effect of Topical Application of Tranexamic Acid on Occult Hemorrhage after Femoral Intramedullary Nail Internal Fixation for Intertrochanteric Fracture

目的探讨局部应用氨甲环酸干预股骨粗隆间骨折股骨防旋髓内钉内固定术后隐性失血的疗效。方法所有患者均选择接受股骨防旋髓内钉内固定术治疗的82例患者,并将其随机分组,分别予以不同治疗方法,观察组经近端扩髓后,对髓腔内局部应用氨甲环酸,对照组经近端扩髓后,对髓腔内局部应用生理盐水,分析两组患者临床治疗效果,探讨局部应用氨甲环酸的干预效果,并分析其临床疗效。结果观察组隐性失血量、显性失血量、围术期总失血量及不良反应率均显著低于对照组,P<0.05,有统计学意义。结论局部应用氨甲环酸干预股骨粗隆间骨折股骨防旋髓内钉内固定术效果显著,能够有效抑制改善术后隐性失血症状,减少失血和输血率,安全性高,值得推广。

Objective To investigate the effect of local application of tranexamic acid on occult hemorrhage after femoral intertrochanteric fracture treated with intramedullary nailing.Methods 82patients with intertrochanteric fracture of femur were treated in our hospital.The observation group was treated with tranexamic acid in the medullary cavity after proximal reaming,and the control group was treated with saline in the medullary cavity after proximal reaming.The clinical effects of tranexamic acid in the two groups were analyzed.Results The occult blood loss,dominant blood loss,total perioperative blood loss and adverse reaction rate in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Local application of tranexamic acid in the treatment of intertrochanteric fracture of the femur with intramedullary nail fixation has a significant effect,can effectively inhibit and improve the postoperative symptoms of occult blood loss,reduce blood loss and transfusion rate,worthy of promotion.