甲状腺素水平与中枢神经系统感染性疾病的相关性分析

Correlation analysis between thyroid hormone level and central nervous system infection disease

目的探讨中枢神经系统感染性疾病患者甲状腺素水平与临床严重程度及预后的相关性。方法选择中枢神经系统感染患者42例(中枢神经感染组),选择同期在本院进行体检的40例健康人群作为对照组。测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)。并将42例中枢神经系统感染患者进行分组比较:①根据临床表现对中枢神经功能障碍分为轻中度感染亚组23例和重度感染亚组19例;②根据预后分为无后遗症亚组29例和后遗症亚组13例。探讨FT3、FT4、TSH水平与临床严重程度及预后的相关性。结果中枢神经系统感染组FT3、FT4、TSH水平较对照组降低,两组间差异有显著性(P<0.05)。中枢神经系统感染组各种病原体感染者间FT3、FT4、TSH水平差异无显著性(P>0.05)。轻中度感染亚组与重度感染亚组FT3水平差异有显著性(P<0.05), FT4、TSH差异无显著性(P>0.05)。后遗症亚组患者FT3、FT4、TSH水平明显低于无后遗症亚组,差异有显著性(P<0.05)。结论血清甲状腺素水平与中枢神经系统感染严重程度及后遗症之间具有相关性,可敏感地反映疾病的严重程度及预后,有助于判断脑损伤的程度及评估患者预后。

Objective To investigate the correlation between thyroid hormone level and severity and prognosis of the patients with central nervous system(CNS) infection disease. Method 42 patients with CNS infection(CNS infection group) were chosen and 40 healthy people were selected as control group. Free triiodothyronine( FT3), free thyroid hormone(FT4) and thyroid stimulating hormone(TSH) were determined. 42 patients with CNS infection were divided into two groups according to their clinical manifestations : ①23 patients with mild to moderate infection subgroup and 19 patients with severe infection subgroup; and ②29 patients with no sequela subgroup and 13 patients with sequela subgroup according to their prognosis. To explore the correlation between FT3, FT4 and TSH levels and clinical severity and prognosis. Result The levels of FT3, FT4 and TSH in CNS infection group were significantly lower than those in control group(P<0.05). There was no significant difference in the levels of FT3,FT4 and TSH among patients with various pathogens in the central nervous system infection group(P>0.05). There was significant difference in FT3 level between mild to moderate infection subgroup and severe infection subgroup(P<0.05), but no significant difference in FT4 and TSH( P>0.05). The levels of FT3, FT4 and TSH in sequelae subgroup were significantly lower than those in no sequelae subgroup(P<0. 05). Conclusion The serum thyroid hormone levels have relationship between with severity and sequela of patients with.central nervous system infection.It can sensitively respond to the severity and prognosis of the disease,which helped to determine the degree of brain injury and evaluate the prognosis of patients.