摘要
目的:优化中药消痛复方膜气雾剂制备工艺。方法:以成膜剂(PVP-K30和HPMC)、润湿剂(甘油)和抛射剂(HFA134a)的用量为考察因素,以喷射效果、成膜速度、成膜性能为评价指标,计算综合评分,设计正交试验优化中药消痛复方膜气雾剂的处方工艺。结果:中药消痛复方膜气雾剂的最佳工艺处方为8%PVP-K30、0.4%HPMC、0.28%甘油、50%HFA134a。结论:该工艺制得的中药消痛复方膜喷雾剂具有雾化效果好,成膜速度快,不易流淌,较柔软的优点。
Objective:To optimize preparation technology of traditional Chinese medicine Xiaotong compound membrane aerosol.Methods:With the dosage of filmogen (PVP-K30 and HPMC),wetting agent (Glycerin)and propellant (HFA134a)as factors,spray effect,film formation rate and film forming properties as evaluation index- es,the orthogonal experiment was designed to optimize preparation technology by calculation comprehensive score.Results:The optimum preparation technology is obtained as 8% PVP-K30,0.4% HPMC,0.28% Glycerin, 50% HFA134a.Conclusion:The traditional Chinese medicine Xiaotong compound membrane aerosol prepared by the optimization technique is spraying well,film forming fastly,flowing hardly and very soft.
作者
张建环
吴涵
王凌
吴雪茹
ZHANG Jian-huan;WU Han;WANG Ling;WU Xue-ru(The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510240,China)
出处
《中医药导报》
2018年第19期84-87,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
2015年中医药强省专项资金医院中药制剂建设项目(粤中医办函[2015]102号)
关键词
中药消痛复方
膜气雾剂
制备工艺
traditional Chinese medicine Xiaotong compound
membrane aerosol
preparation technology
