微小胰腺神经内分泌肿瘤的诊疗进展

Current diagnosis and treatment progress of small pancreatic neuroendocrine neoplasm

微小胰腺神经内分泌肿瘤(pNEN)是pNEN中的一种特殊类型,多数最大径<2cm,发病隐匿,病程缓慢,异质性强。与一般pNEN相比,其诊断过程、干预标准均具有一定的特殊性。近年来,微小pNEN发病率呈迅速上升趋势,但目前临床上对该类肿瘤的诊疗体系尚不成熟,学界争议颇多。本文根据国内外研究进展,对微小胰腺神经内分泌肿瘤的生物学特性、病理分级、定性定位诊断、决策指征、治疗原则进行综述,系统总结微小胰腺神经内分泌肿瘤的诊疗现状。

Small(≤2cm)pancreatic neuroendocrine neoplasm (pNEN)is a very special subgroup of pNEN featuring a small size,concealed pathogenesis,indolent course and remarkable heterogeneity.Differences in its diagnosis and interventional criteria have evolved from routine pNEN.During recent years,the incidence of small pNEN has increased sharply,while optimal management strategy of this subgroup still remains controversial.In this paper,the biological characteristics,pathological classification, diagnosis,intervention indication and therapeutic principles of small pNEN are reviewed based on recent researches,and current situations of diagnosis and treatment of small pNEN are summarized.