注射用奥美拉唑钠2种不同给药方式的稳定性研究

Stability of Two Different Dilution Methods of Omeprazole Sodium for Injection

目的分析与探讨注射用奥美拉唑钠不同给药方式在输液配伍中的稳定性。方法模拟注射用奥美拉唑钠制剂静脉滴注和静脉注射2种临床给药方式,以pH计测定4种溶液在不同时间段的pH值及其变化趋势,UV分别测定2种制剂以不同临床给药方式的全程吸光度值变化,计算奥美拉唑含量,研究其稳定性变化。结果奥克?在3 h后浓度下降明显,仅可用于静脉推注,应配制完尽快使用;奥西康~?在6h内含量变化较小,基本上稳定,可用于静脉滴注。结论 2种注射用奥美拉唑的临床给药方式不同,其稳定性有较大差别,宜严格按照说明书的给药方式给药。

OBJECTIVE To analyze and discuss the stability of different administration ways of omeprazole sodium for injection with transfusion fluid.METHODS Simulated 2 administration ways of omeprazole sodium for intravenous infusion and intravenous injection.The pH value at different periods was determined with pH meter,the differences of full absorbance value using 2 administration ways were measured by UV.Then the contents and the changes of omeprazole sodium were calculated.RESULTS The formulation for injection could only be used for intravenous injection and should be used as fast as possible after diluting as it decreased significantly after 3h.And the other formulation remained stable within 6h and could be used for intravenous infusion.CONCLUSION Due to different administration ways of omeprazole,the stability of 2 formulations vary obviously.So it shall follow the instructions of administration ways of these 2 drugs of omeprazole sodium.