LL-37在类风湿关节炎合并间质性肺病中的作用

Role of LL-37in patients with rheumatoid arthritis-associated with interstitial lung disease

类风湿关节炎(rheumatoid arthritis,RA)是一种病因未明的常见自身免疫性疾病。间质性肺病(interstitial lung disease,ILD)作为RA患者常见的关节外表现,病情进展快,病死率高,且RA-ILD病因尚未完全明确。LL-37是人类天然免疫系统中唯一的抗菌肽cathelicidin家族成员,由于其具有调节免疫系统、促进损伤修复以及抗肿瘤等功能而越来越受到关注。辅助性T细胞17(T helper cell 17,Th17)是一种重要T细胞亚群,在感染免疫、自身免疫性疾病和肿瘤免疫中均有重要作用,且与LL-37在RA-ILD的人群中关系密切。因此,有必要就LL-37在RA-ILD的发生发展中的作用作一简要综述。

Rheumatoid arthritis (RA)is a common autoimmune disease whose etiology is unknown.Interstitial lung disease(ILD)is a common extra-articular manifestation of RA,which can present a rapid progression and high mortality.As the unique member of cathelicidin family,LL-37has drawn more and more attention due to its critical roles in the regulation of immune system,repair of injury and anti-tumor effect.T helper cell 17(Th17)is an important subset of T cells that play a significant role in the infectious immunity,autoimmune diseases ,and tumor immunity.Th17is also closely related to LL-37in the population with RA-ILD.In the present review,we mainly summarize the role of LL-37in the development of RA-ILD.