肿瘤相关髓系细胞在多发性骨髓瘤免疫微环境形成中的作用

Role of tumor-associated myeloid cells in the formation of immune microenvironment in multiple myeloma

尽管多发性骨髓瘤(MM)的治疗取得了显著进步,但MM仍是一种不可治愈的恶性浆细胞肿瘤。研究表明,除了MM细胞本身因素外,MM所在的骨髓微环境也是导致其发生耐药、复发及难治的重要影响因素。MM细胞通过对微环境的重塑,使其不但帮助MM细胞增殖,而且抑制机体免疫系统对MM细胞的杀伤。此外,多种细胞成分和机制在免疫微环境的形成中发挥重要作用,其中肿瘤相关髓细胞(TAMC)越来越受到重视。文章针对TAMC在MM免疫抑制微环境中的作用机制进行综述。

Although great progress has been made in the treatment of multiple myeloma (MM), it is still an incurable malignant plasma cell tumor. In addition to the MM cell itself, the bone marrow microenvironment also plays a critically important role to prompt MM cell's survival, growth, and drug resistance. Bone microenvironment reformed by MM cells could not only help the proliferation of MM cells, but also inhibit the killing of the immune system to MM. A variety of cell components and mechanisms participate in the formation of immune microenvironment, including high-profile tumor associated myeloid cells (TAMC). This paper introduces the mechanisms of TAMC in MM immunosuppressive microenvironment.