Ski在细胞增殖、转化、胶原分泌和炎性反应中的调节作用

The Regulatory Role of Ski in Cell Proliferation, Transformation, Collagen Secretion and Inflammatory Response

ski是病毒癌基因v-ski的细胞内同源物,其蛋白产物Ski参与了造血细胞增殖、肌肉再生、骨和神经系统发育和突触投射以及组织创伤愈合、纤维化、肿瘤发生及增殖等多种生理病理过程。Ski作为一个多功能的转录调节因子,参与了多种分子信号的调节。该文将对Ski在细胞增殖、转化、胶原分泌和炎性反应中的调节作用及机制进行综述。

ski gene is known as the cellular homologue of the avian sarcoma viral oncogene (v-ski). The protein encoded by ski gene is a multifunction regulatory factor in many physiological and pathological processes, which has been reported to be involved in hematopoietic cell proliferation, muscle regeneration, the development of bone and nervous system,synaptic projection,wound healing and fibrosis and tumor growth.These effects are related to a large number of transcription factors and transcriptional co-regulators that interact with Ski by many signaling pathways.Therefore,this article will introduce the regulatory roles and mechanisms of Ski in cell proliferation,transformation,collagen secretion and inflammatory.