常州市3021例放射工作人员染色体畸变率和微核细胞率状况及影响因素分析

Analysis on chromosome aberration rate,micronucleus cell rate and related factors of 3021 radiation workers in Changzhou

目的了解常州市放射工作人员染色体畸变率和微核细胞率状况及影响因素,为保障放射工作人员的职业健康和安全提供依据。方法选取2017年1月1日至12月31日在常州市疾病预防控制中心进行职业健康检查的3021名放射工作人员资料进行描述性分析,并采用logistic回归对体检对象的染色体畸变率、微核细胞率以及影响因素进行分析。结果常州市3021名放射工作人员染色体畸变异常率和微核细胞异常率分别为1.32%和3.34%。多因素logistic回归结果显示接触工龄(OR=1.501,95%CI:1078~2.089,P=0.016)是染色体畸变率的危险因素,放射治疗(OR=6.417,95%CI:1.360~30.280,P=0.019)和介入放射(OR=4.598,95%CI:1.688~12.524,P=0.003)染色体畸变风险高于工业应用;接触工龄(OR=1.245,95%CI:1.007~1.539,P=0.043)也是微核细胞率的危险因素,核医学(OR=3.934.95%CI:1.305~11.858,P=0.015)、放射治疗(OR=3.802,95%CI:1.101~13.128,P=0.035)和介入放射(OR:2.953,95%CI:1.324~6.584,P=0.008)微核细胞率异常风险高于工业应用。结论长期接触低剂量电离辐射的放射工作人员染色体畸变率和微核细胞率与放射工作人员的接触工龄以及所从事的职业类别有关。

Objective To investigate the chromosomal aberration rate,micronucleus cell rate and the related factors of radiation workers in Changzhou,provide evidence for the occupational health and safety of radiation workers.Methods Descriptive analysis of the chromosomal aberration rate,micronucleus cell rate and the related factors of 3021 radiation workers who conducted occupational health examination in the Changzhou Center for Disease Control and prevention in 2017,multivariate logistic regression was used to analyze the data.Results The abnormal rate of chromosome aberration and-micronueleus cells of 3021 radiation workers in Changzhou were 1.32% and 3.34% respectively.The results of multivariate logistic regression showed that the exposure year (OR=1.501,95%CI:1.078~2.089,P=0.016)was a risk factor for chromosome aberration.The risk of chromosome aberration in radiation therapy (OR=6.417,95%CI:1,360~30.280,P=0.019)and interventional radiology (OR=4.598,95%CI:1.688~12.524,P=0.003)was higher than that of industrial application,the exposure year(OR=1.245,95%CI:1.007~1.539,P=0.043)is also a risk factor for micronucleus cell rate.The micronucleus cell rate abnormality Risk of nuclear medicine (OR=3.934,95% CI:1.305-11.858,P=0.015),radiation therapy (OR=3.802,95%CI:1.101~13.128,P=0.035)and interventional radiology (OR =2.953,95%CI:1.324~6.584,P=0.008)is higher than industrial application. Conclusion The chromosome aberration rate and micronucleus rate of workers who are exposed to low dose ionizing radiation for long time are related to the exposure year of radiation workers and the occupational categories involved.