2014-2016年广州市新发现本地户籍HIV/AIDS患者首次CD4^+T淋巴细胞检测分析

The initial CD4^+T lymphocyte test of newly diagnosed HIV/AIDS cases of local residence in Guangzhou in 2014-2016

目的了解2014-2016年广州市新发现本地户籍艾滋病病毒感染者/艾滋病患者(HIV/AIDS)首次CD4^+T淋巴细胞(简称CD4细胞)检测及时性及检测结果。方法选取2014-2016年广州市新发现的本地户籍HIV/AIDS患者CD4细胞检测相关数据进行统计分析。结果纳入的1102例患者中,7d、15d、1个月内完成首次CD4细胞检测的比例依次为67.97%、79.58%、85.57%。首次CD4细胞检测均值为(343.66±214.15)细胞/μl,计数值在≤200细胞/μl、201~350细胞/μl、351~500细胞/μl、>500细胞/μl范围的分别占25.23%、31.40%、25.68%、17.69%。不同性别、年龄、婚姻状况、文化程度、职业、感染途径、发现来源的患者首次CD4细胞检测结果差异有统计学意义(P<0.01)。结论2014—2016年广州市新发现本地户籍HIV/AIDS患者CD4细胞检测及时性逐年提高,但总体免疫水平偏低,晚发现比例逐年提升,亟需加强艾滋病防治宣传,扩大检测覆盖面,及早发现和治疗患者。

Objective To understand the status of initial CD4+T lymphocyte test among newly diagnosed HIV/AIDS cases of local residence in Guangzhou from 2014 to 2016. Methods CD4 test data of 1 102 newly diagnosed HIV/AIDS cases in Guangzhou from 2014 to 2016 were retrieved from the laboratory database and were statistically analyzed. Results 67.97%,79.58%and 85.57%of total cases had their initial CD4 cell testing coithin 7 days,15 days and one month with the mean value of(343.66 ± 214.15)cells/μl.25.23%,31.40%,25.68% and 17.69% of cases had their CD4 count of≤ 200 cells/μl,201~350 cells/μl,351~500 cells/μl and>500 cells/μl.The differences of initial CD4 cell count were statistically significant among patients of different gender,age,marital status,educational level,occupation,infection route and sample source(P<0.01). Conclusions The percentage of newly diagnosed HIV/AIDS patients who have their timely initial CD4 cell test increases annually from 2014 to 2016 in local Guangzhou.The overall immune level is low and the percentage of cases with delayed diagnosis increases each year.Therefore,health education should be enhanced to prevent disease transmission and to diagnose and treat patients early.