髓样细胞激活受体-2对术后认知功能障碍调控的研究进展

Research progress of TREM2 in regulating postoperative cognitive dysfunction

术后认知功能障碍(POCD)是一种急性精神功能紊乱状态,伴有认知以及注意力等的损害,与中枢神经系统炎症密切相关,但其机制仍未探索清楚。TREM2为髓样细胞2触发受体,在小胶质细胞、树突状细胞等多种细胞上表达。DAP12为重要的接头蛋白分子,介导TREM2等受体传递的信号。TREM2-DAP12是一种特异表达于小胶质细胞上的复合体,具有抗炎和促进小胶质细胞吞噬功能的作用。现对TREM2-DAP12的结构、生理功能以及对小胶质细胞在POCD的调控作用以及研究进展进行综述。

Postoperative cognitive dysfunction (POCD)is an acute mental disorder with cognitive and attention impairment,which is closely related to central nervous system inflammation.However,its mechanism is still unclear.TREM2 is the trigger receptor for myeloid cells 2,and is expressed on microglia,dendritic cells and many other cells.TREM2-DAP12is a complex specifically located on microglia and has anti-inflammatory and phagocytic effects.This article reviews the structure,physiological function of TREM2-DAP12 and the regulation of microglia on POCD and the research progress.