47例妊娠期肝内胆汁淤积症临床分析

Clinical Analysis of 47 Patients with Intrahepatic Cholestasis of Pregnancy

目的 探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy, ICP)的临床特点及母婴预后.方法 对2017年7月—2018年5月47 例ICP患者的临床资料进行回顾性分析,比较生化指标、妊娠结局和围产儿情况.结果 70.21%的患者系产检诊断ICP,无明显瘙痒症状;ICP患者的TBA、ALT和AST水平显著高于对照组,差异具有统计学意义(P<0.01);ICP组的剖宫产、羊水污染和早产儿、低体重儿比例高于对照组,差异具有统计学意义(P<0.05);两组新生儿1 min、5 min的Apgar评分比较,差异无统计学意义(P>0.05).结论 ICP是母婴预后不良因素,临床需要早期诊断、合理干预.

Objective To explore the clinical features and maternal and child prognosis of intrahepatic cholestasis of pregnancy (ICP).Methods The clinical data of 47 patients with ICP from July 2017 to May 2018 were analyzed retrospectively.The biochemical indexes,pregnancy outcomes and perinatal conditions were compared.Results 70.21% of the patients were diagnosed as ICP by obstetric examination without obvious itching symptoms.The levels of TBA,ALT and AST in patients with ICP were significantly higher than those in control group (P <0.01).The rates of cesarean section,amniotic fluid contamination,premature infants and low birth weight infants in ICP group were significantly higher than those in control group (P <0.05).There were no significant differences in the Apgar scores at 1 min and 5 min between the two groups (P >0.05).Conclusion ICP is a poor factor for maternal and infant prognosis.Early diagnosis and reasonable intervention are needed in clinic.