摘要
《中国药典(2015版)》收录了43个记载为"小毒"的常用中药,其中仙茅、金铁锁及香加皮均有祛风除湿的功效,其药性也都为"小毒"。本文综合历代本草文献和现代研究文献资料,从其毒的历史认识过程,引起毒性反应的物质基础和分子机制进行分析,并从毒性反应的临床主要表现及对策,评价毒性反应与药效活性的关系,进行综合评价,为全面认识这些中药的毒性和临床合理应用提供参考。
CurcuUginisRhizoma,Psammosilenes Radix and Pefiplocae Cortex are included in China pharmacopoeia (2015edition)as low toxic drugs.These three traditional Chinese medicines are recorded to have the activity of expelling wind-evil and removing wetness.In this review,we summarized the historical literatures of their toxicity and combined them with modem researches to evaluate the relationship between toxicity and pharmacdogical activity.Also we analyzed the historical cognition process,material base and molecular mechanism of toxicity and comprehensively concluded the clinical reaction of toxicity response and its countermeasure for these drugs.This review win provide important references for scientific cognition of the toxicity and appropriate clinical application of the three traditional Chinese medicine.
作者
王霖
张雪
孔令雷
杜冠华
Wang Lin;Zhang Xue;Kong Linglei;Du Guanhua(Drug target research and new drug screening key laboratory of Beijing,Institute of medicine,Peking union medical college,Chinese aeademy of medical sciences,Beijing 100050;Interdisciplinary science research institute of Shanghai university of tradltlonal Chinese medieine,Shanghai 201203)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2018年第5期157-160,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家药典委员会项目(2017开0150号).
关键词
仙茅
金铁锁
香加皮
历史认识
毒性反应
药效活性
CurculiginisRhizoma
Psammosilenes Radix and Pefiplocae Cortex
historical understanding
toxic effect
pharmacdogical activity
