生殖支原体与女性泌尿生殖道疾病研究进展

Advances in the research of mycoplasma genitaliumand female urogenital tract diseases

生殖支原体目前被认为是除沙眼衣原体之外最常见的性传播病原体,尤其是在有高危因素的女性人群中,其感染率较一般人群显著升高。然而,不同于在男性中较为确切的作用,生殖支原体在女性泌尿生殖道疾病中的作用还不十分清楚。近年来,除既往关注较多的与宫颈炎、盆腔炎性疾病的相关性外,关于其与各种妊娠不良结局以及艾滋病病毒感染之间关系的研究也有所深入,但仍需要进一步的研究提供更加充分的证据。同时,对于生殖支原体感染的分子机制也有待更多的探索。

Mycoplasma genitaliumis currently considered to be the most common sexually transmitted pathogen in addition to chlamydia trachomatis.The infection rate is significantly higher in women with high-risk factors than that of the general population.Yet unlike the precisely pathogenic role of mycoplasma genitalium in males,the role in female urogenital tract diseases is not clear.Emerging data demonstrate associations between M.genitalium and adverse pregnancy outcomes and HIV infection besides cervicitis and pelvic inflammatory diseases that have received much attention in the past.However further researches are needed to provide more evidences.At the same time,the molecular mechanism of its infection remains to be explored.