巨噬细胞与肿瘤发展及其靶向治疗

The effect of macrophage on tumor development and its targeted therapy

巨噬细胞作为机体固有免疫的重要组成部分,有着广泛的生物学功能,如维持机体内稳态和抵御外来病原体等,同时也是一类具有高度可塑性和异质性的细胞群体.因此,巨噬细胞功能正常与否在多种疾病如肿瘤、纤维化及糖尿病发展过程中有着重要作用.在肿瘤发展过程中,肿瘤相关巨噬细胞(tumor-associated macrophages,TAM)是肿瘤微环境中的重要组成部分,具有促进肿瘤生长、调节肿瘤血管生成、侵袭、转移和免疫抑制等功能.通常肿瘤中TAM的丰富程度与不良预后相关.现就巨噬细胞的来源分化、TAM在肿瘤微环境中的作用及TAM靶向治疗作为一种新型间接肿瘤治疗策略的前景作一综述.

As an essential innate immune population for maintaining body homeostasis and warding off foreign pathogens,macrophages perform diverse supportive functions specialized to different tissue compart-ments,such as maintaining homeostasis in the body and resisting foreign pathogens. Macrophage is also a type of cells that displayed high plasticity and heterogeneity. Consequently,aberrance in macrophage functions contrib-utes substantially to progression of several diseases including cancer,fibrosis,and diabetes. In the context of cancer,tumor-associated macrophages(TAM)are an important component of the tumor microenvironment. TAM typically promote cancer cell proliferation,immunosuppression,and angiogenesis in support of tumor growth and metastasis. Oftentimes,the abundance of TAM in tumor is correlated with poor disease prognosis. This review aims to introduce the origin and differentiation of macrophages,as well as the effect of TAM on tumor in tumor microenvironment. At the end,we discusses the prospects of TAM targeted therapy as a novel indirect tumor treatment strategy.