多能干细胞向甲状腺滤泡细胞的诱导分化

Inducing differentiation of pluripotent stem cells into thyroid follicular cells

多能干细胞(PSCs)是一种特殊的干细胞群,具有自我更新、无限增殖和向3个胚层多向分化的潜能。PSCs包括胚胎干细胞和诱导多能干细胞,为疾病模型的构建、细胞替代性治疗和药物研发等方面,提供了无限的细胞来源。近期,PSCs通过3-D培养形成甲状腺类器官的研究已成为热点,这项技术基于PSCs向甲状腺滤泡细胞的诱导分化。

Pluripotent stem cells (PSCs)are a special group of stem cells characterized by their capability to self-renew,infinite proliferation and the potential to differentiate into all derivative cell types of the three germ layers.PSCs,including embryonic stem cells and induced pluripotent stem cells,provide a unlimited cell source to build disease modeling,study cell-replacement therapy and facilitate drug discovery. Recently,thyroid organoids,generated from PSCs through the development of three-dimensional culture systems,have become a hot topic.This technology builds upon a foundation of inducing PSCs.