摘要
The crystal structure of the natural terpene derivative（2,4-dihydroxy-3,6-dimethoxyphenyl）(（1 R,2 S,3 S,4 R,7 R）-7-isopropyl-5-methyl-3-phenylbicyclo[2.2.2]oct-5-en-2-yl)-methanone was determined by single-crystal X-ray diffraction method. The compound crystallizes in triclinic,space group P21/c with a = 16.1444（9）, b = 16.5294（9）, c = 19.7875（11） ?, V = 5280.4（5） ?3, Z = 4,Dc = 1.209 g/cm;, F（000） = 2064, μ（Cu Kα） = 0.675 mm-1, S = 1.069, R = 0.0520 and wR(I > 2σ（I）)= 0.1392. The spiro structure constructed by Diels-Alder reaction was highly symmetric. In addition,the title compound showed inhibitory activities against cancer cell line with varied potencies.
The crystal structure of the natural terpene derivative(2,4-dihydroxy-3,6-dimethoxyphenyl)((1 R,2 S,3 S,4 R,7 R)-7-isopropyl-5-methyl-3-phenylbicyclo[2.2.2]oct-5-en-2-yl)-methanone was determined by single-crystal X-ray diffraction method. The compound crystallizes in triclinic,space group P21/c with a = 16.1444(9), b = 16.5294(9), c = 19.7875(11) ?, V = 5280.4(5) ?3, Z = 4,Dc = 1.209 g/cm^3, F(000) = 2064, μ(Cu Kα) = 0.675 mm-1, S = 1.069, R = 0.0520 and wR(I > 2σ(I))= 0.1392. The spiro structure constructed by Diels-Alder reaction was highly symmetric. In addition,the title compound showed inhibitory activities against cancer cell line with varied potencies.
基金
financially sponsored by Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai(2017YQ048)
China Postdoctoral Science Foundation(2017M610278)
National Nature Science Foundation of China(No.81730102)
Shanghai Rising-Star Program(16QB1403800)
