HBV受体研究新进展

Recent advances in the study of HBV receptor

HBV流行久远、传播广泛。HBV感染所致的乙型肝炎一直是全球性公共卫生问题。HBV通过与靶细胞表面的受体结合从而启动感染。HBV被发现后的四十余年中,人们一直致力于寻找其受体,虽有诸多报导但均未被认可,直到Na^+-牛磺胆酸共转运蛋白(NTCP)被鉴定为HBV的功能性受体并得到了公认。这一发现使得人们对HBV的感染机制有了进一步认识,并为HBV的基础研究与临床治疗提供了新的方向。

Hepatitis B virus (HBV)has long been prevalent and widespread.Hepatitis B caused by HBV infection has always been a global public health problem.HBV initiates infection by binding to a receptor on the surface of the target cell.Researchers have been dedicated to finding the receptor of HBV for more than 40 years since HBV was discovered. Many studies have been reported,but none have been accepted until sodium taurocholate cotransporting polypeptide (NTCP)was identified and recognized as a functional receptor for HBV.This discovery has led to further understanding of the mechanism of infection of HBV and it provides a new direction for basic research and clinical treatment of HBV.