肺部吸入纳米药物递送系统治疗肺癌的研究进展

Inhalable Nanocarrier-based Drug Delivery Systems for Lung Cancer Therapy

肺部吸入给药系统在治疗肺癌的应用中取得了很大的进展。肺部吸入途径是非侵入性的给药方法,可以将抗肿瘤药物局部递送到肺肿瘤组织。纳米制剂提高了难溶性抗肿瘤药的溶解性,并延缓了药物的释放。通过表面修饰开发主动靶向纳米粒,增强了对肺癌细胞的特异性,减少了对正常细胞的毒性。本文综述了各种吸入纳米给药系统的特点及其在肿瘤靶向给药方面的应用,包括聚合物、脂质和杂合纳米载体,还阐述了增强纳米载体对肺癌细胞选择性的各种主动靶向策略。

There is a progressive evolution in the use of inhalable drug delivery systems for lung cancer therapy. The inhalation route offers many advantages,being non-invasive method of drug administration as well as localized delivery of anti-cancer drugs to rumor tissue.Pulmonary delivery of chemotherapy via inhalable nanocarriers has gained more attention in recent years due to their ability to improve solubility of poorly soluble drugs and keep their sustained- release,in addition to their ability to target cancer tissues in the lungs. Moreover,nanocarriers can be taken up into the cancer cells via endocytosis,leading to improved anti-tumor activity compared with the free drug.This article reviews various inhalable colloidal systems studied for tumor-targeted drug delivery including polymeric,lipid and hybrid nanocarriers.Actively targeted nanoparticles could be developed via surface modification to enhance nanoparticles accumulation into lung cancer cells via receptor-mediated endocytosis.Various active targeting approaches sorted based on cellular target are also illustrated.