维生素D缺乏与儿童肥胖

Vitamin D deficiency and childhood obesity

维生素D(VD)缺乏和儿童肥胖已成为两大公共卫生问题。随着人们对VD骨外效应的逐渐认识,VD与儿童肥胖的关系已成为研究热点。近年来大量国内外研究表明VD缺乏与肥胖及其相关代谢性疾病存在相关性;肥胖人群血清VD水平明显低于正常体重人群,且孕期母体VD缺乏与子代体重超重密切相关;对肥胖人群进行VD的补充治疗有助于降低体重指数,但VD与肥胖之间的因果关系仍不明确,且相关机制仍未完全阐明。本文就VD缺乏与儿童肥胖的流行病学特征、两者之间的关系及其可能的相关机制进行阐述。

Vitamin D(VD)deficiency and childhood obesity have become two public health problems.With the increasing recognition of the extra-bone effects of VD,the relationship between VD and childhood obesity has become a hot research topic.In recent years,more and more studies have demonstrated that VD deficiency is associated with obesity and other metabolic diseases.The serum level of VD in obese population is significantly lower than that in normal weight population.And maternal VD deficiency during pregnancy is closely related to the overweight of offspring,VD supplementation for obese population helps lower body mass index.However,the causal relationship between VD deficiency and obesity is still unclear,and the underlying mechanism has not been fully elucidated either.This review summarizes the epidemiological characteristics of VD deficiency and childhood obesity,the correlation and the underlying mechanism.