半乳糖凝集素-1与胃癌侵袭及转移关系的研究进展

Research progress on relationship between galectin-1 and invasion and metastasis of gastric cancer

目的探讨半乳糖凝集素-1(Gal-1)与胃癌侵袭及转移间的关系。方法对近年来国内外有关Gal-1与胃癌侵袭及转移关系研究的相关文献进行综述。结果胃癌组织中Gal-1的表达与肿瘤细胞的侵袭力、转移能力、免疫抑制、血管生成等密切相关,在胃癌的进展与演变过程中发挥重要作用;Gal-1表达越高,提示肿瘤的恶性程度越高,患者的预后越差。结论 Gal-1的表达可促进胃癌的侵袭和转移,但仍需进一步临床研究予以验证。

Objective To investigate relationship between galectin-1(Gal-1) and invasion and metastasis of gastric cancer. Method The related literatures on the relationship between the Gal-1 and the invasion and metastasis of gastric cancer in recent years were reviewed. Results The expression of Gal-1 in the gastric cancer tissue was closely related to the invasion, metastasis ability, immunosuppression, and angiogenesis of tumor cells, and played the important role in the progression and evolution of the gastric cancer. The expression of Gal-1 was higher, the malignancy of the tumor was higher, and the prognosis of the patient was worse. Conclusion Expression of Gal-1 can promote invasion and metastasis of gastric cancer, but further clinical trials need to be verified.