理肺通络合剂联合地塞米松注射液对支原体肺炎免疫指标的影响研究

Effect of Lung and Dredging Collaterals Mixture Combined with Dexamethasone Injection on Immune Index for Patients with Mycoplasma Pneumonia

目的:探讨理肺通络合剂与地塞米松注射液联用在支原体肺炎患者中的临床疗效及对患者免疫指标的变化影响。方法:选择医院2014年2月一2015年11月接收治疗的148例支原体肺炎患者。按照患者入院先后顺序标记为奇数号与偶数号,奇数号患者作为对照组,偶数号患者作为治疗组,每组74例。对照组患者采用地塞米松注射液治疗,治疗组采用理肺通络合剂与地塞米松注射液联合用药,7d为1个疗程,两组分别连续治疗2个疗程。评价两组治疗后的临床总有效率,统计分析两组患者治疗前后免疫功能指标(IgA、IgM、IgG、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)的变化。结果:①治疗组与对照组的临床总有效率分别为98.65%(73/74)、78.38%(58/74),两组比较差异具有统计学意义(P<0.05);②治疗前两组各项指标比较无统计学差异性(P>0.05),治疗后两组血清IgA、IgM、IgG均升高,治疗组各项指标变化趋势更加明显,与对照组比较有统计学差异性(P<0.05);③治疗后两组CD4^+、CD4^+/CD8^+均升高,CD3+、CD8^+均升高,治疗组指标降低或升高程度与对照组比较更加显著,具有显著性统计学差异性(P<0.05)。结论:理肺通络合剂联合地塞米松注射液用于支原体肺炎疾病的治疗中,与单纯地塞米松注射液比较具有更加显著的临床疗效,同时提高了患者的免疫抵抗能力,加快了患者疾病的恢复时间,是临床上值得采用的中西医结合治疗方式。

Objective :To explore the clinical efficacy and the effect of the changes of lung and dredging collaterals mixture combined with dexamethasone injection on the immune index for patients with mycoplasma pneumonia.Methods :A total of 148 cases of mycoplasma pneumonia in our hospital from February 2014 to November 2015 were chosen.According to the order of admission,the patients which were odd numbers were as the control group and those which were the even numbers were as the treatment group,and 74 cases in each group.The control group was treated with dexamethasone injection treatment,and the treatment group was treated with lung and dredging collaterals mixture combined with dexamethasone injection.Seven days were as a course of treatment,and both groups were treated for continuous treatment of 2 courses.The total clinical effective rates were taken for evaluation,and the changes of the immune function parameters (IgA,IgM,IgG,CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)for the two groups of patients before and after treatment were taken for statistical analysis.Results :①The clinical total efficiency rates of the treatment group and the control group were 98.65%(73/74)and 78.38%(58/74),and the differences had statistical significance (P <0.05).②Before treatment,the indicators of the two groups were without significant differences (P >0.05).After treatment,the serum IgA, IgM and IgG were increased,and the trend indicators were more obviously in the treatment group.Compared with the control group,there were with statistical differences (P <0.05).③After treatment,the CD4^+、CD4^+/CD8^+and CD3+、CD8^+ were increased.The levels of increasing and decreasing in the treatment group were more significant than those of the control group,and there were with statistical significant differences (P <O.05).Conclusion:The clinical effect of lung and dredging collaterals mixture combined with dexamethasone injection for patients with mycoplasma pneumonia compared with the simple dexamethasone injection is more significant.It can improve the patients'immune resistance,accelerate the recovery time of patients,and it is worthy of the clinical application of integrative medicine.