胃癌组织中TFF3和PDGFR的表达及临床意义

The expression and clinical significance of TFF3 and PDGFR in gastric carcinoma

目的检测TFF3和PDGFR在人的胃癌组织中的表达状况,分析二者表达的相关性及其与临床病理特征的联系,探讨TFF3和PDGFR在胃癌的发生、发展过程中的作用及二者可能的相互机制。方法采用免疫组织化学Elivision染色法,检测蚌埠医学院第一附属医院自2010年7月—2011年6月间,60例胃癌标本及每例标本所对应的癌旁正常组织中TFF3和PDGFR的表达情况,比较胃癌组织与癌旁正常组织中TFF3和PDGFR表达的差异,分析两者表达与临床病理特征的关系以及二者间的相互关系。结果TFF3阳性表达位于细胞质和细胞膜中,在胃癌组织中表达的阳性率明显高于癌旁正常胃组织,差异具有统计学意义(P<0.05),TFF3的表达与TNM分期(P=0.007)及淋巴结转移(P=0.003)因素有关;PDGFR阳性表达位于细胞质中,在胃癌组织中表达的阳性率明显高于癌旁正常胃组织,差异具有统计学意义(P<0.05),PDGFR的表达与TNM分期(P=0.001)、淋巴结转移(P=0.010)及有无突破浆膜层(P=0.004)等因素有关。胃癌组织中TFF3和PDGFR的表达呈正相关(r=0.348,P=0.007)。结论TFF3与PDGFR在胃癌组织中的表达呈正相关,提示它们之间可能存在某种协同机制,共同参与了胃癌的发生和发展。联合检测胃癌组织中TFF3和PDGFR的表达有助于对胃癌恶性程度和侵袭能力的判断。

Objective To investigate the expressions of TFF3 and PDGFR in human Gastric carcinoma and analyze the relationship between them and tumor clinicopathological features as well as the role of TFF3 and PDGFR in the metastasis and invasion. Methods The expression of TFF3 and PDGFR in 60 cases of gastric cancer and corresponding adjacent non tumor tissue were detected by immunohistochemistry,which were from July,2010 to June,2011 in the First Affiliated Hospital of Bengbu Medical College,and then the relationship between TFF3,PDGFR expressions and clinicopathology were analyzed. Results The expression of TFF3 was located in cell membrane and cytoplasm,a significant difference was observed between gastric carcinoma and in adjacent non tumor tissue( P < 0. 05) . The expression of TFF 3 was related to tumor TNM stage( P = 0. 007) and lymph node metastasis( P = 0. 003) . The expression of PDGFR was located in cytoplasm,a significant difference was observed between the groups( P < 0. 05) . The expression of PDGFR was related to TNM stage( P = 0. 001) ,lymph node metastasis( P = 0. 010) and serosal layer breakthrough( P = 0. 004) . TFF 3 expression was positive correlated with PDGFR( r = 0. 348,P = 0. 007) . Conclusion There is statistically positive correlation between TFF 3 and PDGFR expression,which indicates that they may participate in the occurrence and development of gastric carcinoma. Combination of TFF3 and PDGFR detection may be helpful to evaluate the capability of the tumor invasion and diversion of gastric carcinoma.