摘要
建立基于妊娠期女性的生理药代动力学(p-PBPK)模型可以更好地理解和预测药物在妊娠期药代动力学的变化。本文拟对p-PBPK模型的研究现状及应用情况进行综述。
In order to better understand and predict the changes of drug pharmacokinetics during pregnancy,in recent years,a model of pregnancy - based physiologically-based pharmacokinetic (p-PBPK) was established. This paper summarizes the research status and application of p-PBPK model.
作者
鲁娣
宋殿荣
LU Di;SONG Dian-rong(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 300193, China;Department of Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2018年第23期2784-2786,共3页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81573740)
关键词
妊娠期
生理药代动力学模型
研究进展
应用现状
pregnancy
physiological pharmacokinetic model
researchprogress
application status
