摘要
萘醌类成分是传统中药紫草中一类重要的活性成分。近年来,国内外对紫草萘醌类成分药理及临床应用的研究已逐渐深入,并取得了较大进展。与此同时,由于紫草类药材来源复杂、质量差异明显,以多种萘醌类成分作为质量标志物进行紫草及其产品的定量分析及质量评价受到了越来越多的关注,其研究亦逐步增多。本文综述了以紫草素为代表的紫草萘醌类成分的药理作用及多组分含量测定方法的最新研究进展,拟为进一步研究和开发紫草药用资源、建立其更为全面系统的质量控制与品质评价方法提供参考。
Naphthoquinones are a kind of important active ingredients in the traditional Chinese medicinal herb "Zicao".In recent years,researches on pharmacology and clinical application of naphthoquinones in Zicao have been gradually deepened and made extensive progress around the world.On the other hand,the plant origins of the herbal materials of Zicao in market are complex and their qualities are quite different,thus more and more studies have been focused on the quantitative determination and quality assessment of the medicinal herb as well as its products by using various naphthoquinones as quality chemical markers.In this paper,we review recent advances in the research on pharmacological actions and multi-components content determination of shikonin/alkannin and its derivatives in Zicao so as to provide a scientific guidance for further research and development of medicinal resource of Zicao,and to establish more comprehensive and systematic method for their quality control and evaluation.
作者
程敏
汤俊
李姗姗
CHENG Min;TANG Jun;LI Shan-shan(Wuhan institute for Drug and Medical Device Control,Wuhan 430075,China;Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Wuhan University School of Pharmaceutical Sciences,Wuhan 430071,China)
出处
《药学学报》
CAS
CSCD
北大核心
2018年第12期2026-2039,共14页
Acta Pharmaceutica Sinica
基金
湖北省食品药品监督管理局科研项目(201601021)
国家自然科学基金面上项目(31270401).
关键词
紫草
萘醌类成分
药理活性
质量标志物
定量分析
品质评价
Zicao
naphthoquinones
pharmacological action
quality marker
quantitative analysis
quality evaluation