新型天麻素中间体类似物的高效合成（英文）

Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues

在葡萄糖酸的催化作用下,以4-甲酰基苯基-2,3,4,6-O-四乙酰基-β-D-葡萄糖苷和1,3-二噁烷-4,6-二酮为原料,发生Knoevenagel缩合反应合成了10种新型天麻素中间体类似物.该反应具有收率高(78%～92%)、反应温和、操作简单及环境友好等优点.此外,葡萄糖酸还可重复使用.

Ten gastrodine intermediate analogues were synthesized by the Knoevenagel reaction of 4-formylphenyl(2,3,4,6- tetra-O-acetyl)-β-D-glucoside and 1,3-dioxane-4,6-dione with gluconic acid as a catalyst.In this reaction there are many advantages with good to excellent yields (78%-92%),mild conditions,simple operations and environmental friendliness.Addi- tionally,gluconic acid could be recycled and reused many times without lossing its efficiency.