四溴化碳促进下2-(1H-苯并[d]咪唑)-3-芳基丙烯腈的高效合成

CBr4-Promoted Efficient Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)-3-arylacrylonitriles

2-苯并咪唑-3-芳基丙烯腈衍生物具有广谱的生物活性,同时还是一类重要的合成中间体,在有机合成领域具有广泛的应用.以芳醛和2-氰甲基苯并咪唑为原料,乙醇为溶剂,在四溴化碳促进下,高效合成了2-(1H-苯并[d]咪唑)-3-芳基丙烯腈.反应在回流条件下搅拌5～10 min即可完成,以74%～96%的产率得到目标产物.该方法为2-苯并咪唑-3-芳基丙烯腈衍生物的制备提供了反应条件温和、后处理方便和底物适用范围广的合成策略.

2-(1H-Benzo[d]imidazol-2-yl)-3-arylacrylonitrile derivatives not only exhibit a variety of important biological activities,but also are important intermediates in organic synthesis.The CBr4-promoted reaction of aromatic aldehydes with 2-(1H-benzo[d]imidazol-2-yl)acetonitrile to obtain 2-(1H-benzo[d]imidazol-2-yl)-3-arylacrylonitriles was developed.Structurally diverse 2-(1H-benzo[d]imidazol-2-yl)-3-arylacrylonitriles were obtained in moderate to good yields(74%~96%) under mild conditions.This method has the advantages of operational simplicity and wide substrate scope.