小牛血清去蛋白注射液联合奥扎格雷治疗老年脑梗死的临床研究

Clinical study of deproteinized calf blood serum injection combined with ozagrel in the treatment of senile cerebral infarction

目的探讨小牛血清去蛋白注射液联合奥扎格雷治疗老年脑梗死的临床效果。方法将2016年6月至2017年6月某院收治的老年脑梗死患者136例,按随机数表法分为两组,各68例。对照组予奥扎格雷静脉滴注治疗;观察组在此基础上,予小牛血清去蛋白注射液静脉滴注。连续治疗14 d后,比较两组患者临床疗效、神经功能、血液流变学指标及不良反应情况。结果治疗14 d后,观察组总有效率95.59%,明显高于对照组80.88%,差异具有统计学意义(P<0.05);治疗后观察组NIHSS评分低于对照组,MMSE评分高于对照组,差异均有统计学意义(P<0.05);治疗后观察组全血黏度、血浆黏度、血小板聚集率明显低于对照组,差异有统计学意义(P<0.05);观察组不良反应率为5.88%,对照组为8.82%,两组比较,差异无统计学意义(P>0.05)。结论小牛血清去蛋白注射液联合奥扎格雷治疗老年脑梗死临床疗效及安全性好,能够明显降低老年患者神经功能损伤。

Objective To investigate the clinical effect of deproteinized calf blood serum injection combined with ozagrel in the treatment of senile cerebral infarction.Methods 136 senile patients with cerebral infarction admitted in a hospital from June,2016 to June,2017 were selected and divided into two groups by random number table,with 68 cases in each group.The control group was given intravenous drip of ozagrel while the observation group was given intravenous drip of deproteinized calf blood serum injection and intravenous drip of ozagrel.After 14 days of treatment,the clinical efficacy,nerve function,hemorheology indexes and adverse reactions were compared between the two groups.Results After 14 days of treatment,the total effective rate of the observation group(95.59%)was significantly higher than that of the control group(80.88%)and the difference showed statistical significance (P <0.05).After the treatment,the NIHSS score of the observation group was lower than that of the control group while the MMSE score of the observation group was higher than that of the control group.The difference showed statistical significance(P <0.05).After the treatment,the blood viscosity,plasma viscosity,platelet aggregation rate in the observation group were significantly lower than those in the control group and the difference showed statistical significance (P <0.05).The incidence rate of adverse effect of the observation group was 5.88% while the rate of the control group was 8.82%.There was no statistical difference between the two groups(P >0.05).Conclusion Deproteinized calf blood serum injection combined with ozagrel in the treatment of senile cerebral infarction was effective and safe which could significantly decrease nerve function injury among senior patients.